LARGER VIALS = LARGER SAVINGS PER mg

GHK-CU

GHK-CU

$42.00
$42.00
SAVE Liquid error (snippets/price line 116): Computation results in '-Infinity'% Sold out

science Lab-Tested 99% Purity

local_shipping Fast, Discreet Shipping

school For Research Use Only

 
add_shopping_cart

-

Ordered

local_shipping

- - -

Order Ready

redeem

- - -

Delivered

GHK-CU

GHK-CU

$42.00
$42.00
SAVE Liquid error (snippets/price line 116): Computation results in '-Infinity'% Sold out

GHK-Cu (Copper Tripeptide-1) is a naturally occurring peptide complex consisting of glycine-histidine-lysine bound to copper ions. It has been studied for its regenerative properties, including stimulation of collagen synthesis, promotion of wound healing, anti-inflammatory effects, and potential applications in skin and hair health.

View full details
  • DESCRIPTION
  • STORAGE
  • REFERENCES

GHK-Cu (Copper Tripeptide-1) is a naturally occurring copper-binding peptide composed of the tripeptide sequence glycyl-L-histidyl-L-lysine complexed with copper(II). First identified in human plasma in 1973, GHK-Cu is widely studied for its role in wound healing, tissue regeneration, skin remodeling, and hair growth. It is also known for its anti-inflammatory, antioxidant, and DNA repair–supportive properties, making it a key focus in anti-aging and regenerative medicine research.

Structure

  • Sequence: Gly-His-Lys (GHK)
  • Molecular Weight (GHK-Cu): ~403 Da
  • Form: Copper(II) complex of the GHK peptide
  • Mechanism: Binds copper ions, facilitating enzymatic and cellular repair processes

Research

Skin Regeneration & Anti-Aging

  • GHK-Cu stimulates collagen, elastin, and glycosaminoglycan synthesis, leading to improved skin elasticity and reduced wrinkles in clinical studies.
  • Enhances wound contraction, tissue remodeling, and angiogenesis in injured skin.

Hair Growth

  • Topical and injectable forms of GHK-Cu have been shown to stimulate hair follicle activity and increase hair density, possibly through Wnt signaling activation and anti-inflammatory pathways.

Anti-Inflammatory & Antioxidant Actions

  • GHK-Cu downregulates pro-inflammatory cytokines (e.g., TNF-α, IL-6) and reduces oxidative stress.
  • Protects tissues from free radical damage by enhancing superoxide dismutase (SOD) activity.

DNA Repair & Gene Modulation

  • Genomic studies show GHK-Cu can reset gene expression in human cells, upregulating hundreds of genes linked to regeneration while downregulating those associated with cancer, fibrosis, and inflammation.

Wound Healing & Organ Protection

  • Promotes angiogenesis and fibroblast proliferation, accelerating wound healing in skin, muscle, and bone.
  • Studies suggest protective roles in lung, liver, and nerve repair.

Safety Profile

  • GHK-Cu is endogenously present in plasma, saliva, and urine.
  • Clinical use in cosmetics and wound care demonstrates an excellent safety profile.

Summary

GHK-Cu is a copper-binding tripeptide with broad biological activity in tissue regeneration, wound repair, and skin health. Research highlights include:

  • Collagen and elastin stimulation for anti-aging and skin rejuvenation
  • Hair follicle activation and hair density improvement
  • Anti-inflammatory and antioxidant properties
  • Gene modulation supporting repair and protection pathways

Its strong safety record and multifunctional effects make GHK-Cu one of the most extensively studied peptides in regenerative and aesthetic research.

This peptide is supplied as a lyophilized powder. Store vials at 2–8 °C, protected from light and moisture. For long-term storage, keep unopened vials at −20 °C. After reconstitution, prepare under sterile conditions, refrigerate at 2–8 °C, and use promptly. Avoid repeated freeze–thaw cycles to preserve stability.

1. Pickart L, et al. A tripeptide in human plasma that prolongs survival of normal liver cells and decreases tumor growth. Nature. 1973;243:85–87. doi:10.1038/243085a0

2. Pickart L, Thaler MM. Tripeptide in human serum which prolongs survival of hepatocytes in culture. Nature New Biol. 1973;243(124):85–87.

3. Maquart FX, et al. Stimulation of collagen synthesis in fibroblast cultures by the tripeptide-copper complex GHK-Cu. FEBS Lett. 1988;238(2):343–346. doi:10.1016/0014-5793(88)80476-3

4. Pickart L, Margolina A. Regenerative and protective actions of the GHK-Cu peptide in the skin. J Aging Sci. 2012;1(1):1–7. doi:10.4172/2329-8847.1000102

5. Siméon A, et al. GHK-Cu and tissue remodeling: stimulation of proteoglycan synthesis. J Invest Dermatol. 2000;115(6):962–968. doi:10.1046/j.1523-1747.2000.00164.x

6. Pickart L, Vasquez-Soltero JM, Margolina A. The human tri-peptide GHK and its copper complex reset gene expression. Biomed Res Int. 2014;2014:151479. doi:10.1155/2014/151479

7. McCormack MC, et al. The role of copper peptides in wound healing. Wound Repair Regen. 2012;20(6):853–861. doi:10.1111/j.1524-475X.2012.00829.x

8. Hino N, et al. Copper peptide GHK-Cu as a modulator of hair follicle activity. J Dermatol Sci. 2005;40(2):137–139. doi:10.1016/j.jdermsci.2005.07.004

9. Alper G, et al. Anti-inflammatory effects of GHK-Cu in wound healing. Clin Cosmet Investig Dermatol. 2015;8:407–412. doi:10.2147/CCID.S88690

10. Pickart L, Margolina A. GHK-Cu: a wound healing and anti-aging peptide that regulates gene expression. Ann N Y Acad Sci. 2012;1270:58–67. doi:10.1111/j.1749-6632.2012.06466.x