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Melanotan 2

Melanotan 2

$48.00
$48.00
SAVE Liquid error (snippets/price line 116): Computation results in '-Infinity'% Sold out

science Lab-Tested 99% Purity

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Melanotan 2

Melanotan 2

$48.00
$48.00
SAVE Liquid error (snippets/price line 116): Computation results in '-Infinity'% Sold out

Melanotan II (MT-2) is a synthetic analogue of α-melanocyte-stimulating hormone (α-MSH) that acts as a non-selective melanocortin receptor agonist. It has been studied for its ability to increase skin pigmentation, enhance sexual function, and modulate appetite, though its clinical use remains experimental.

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  • DESCRIPTION
  • STORAGE
  • REFERENCES

Melanotan 2 (MT-2) is a synthetic cyclic analogue of α-melanocyte-stimulating hormone (α-MSH). It binds to multiple melanocortin receptors (MC1R, MC3R, MC4R, and MC5R), inducing diverse biological effects including increased skin pigmentation, appetite modulation, and sexual function enhancement. Unlike Melanotan 1, which is selective for MC1R, Melanotan 2 has broader receptor activity, making it a subject of research in tanning, obesity, and sexual dysfunction.

Structure

  • Type: Synthetic cyclic heptapeptide analogue of α-MSH
  • Molecular Weight: ~1024 Da
  • Mechanism:



    MC1R agonism: Stimulates melanin synthesis → skin pigmentation and photoprotection



    MC3R/MC4R agonism: Modulates appetite and sexual arousal pathways in the CNS



    MC5R activity: Linked to exocrine gland function and energy metabolism

Research

Pigmentation & Photoprotection

  • Increases eumelanin production and enhances resistance to UV-induced DNA damage.
  • Studied as a tanning agent and in photoprotection against skin cancer risk.

Sexual Function

  • Stimulates MC4R in the hypothalamus → increases libido and erectile response.
  • Investigated in male erectile dysfunction and female sexual arousal disorder.

Appetite & Metabolic Regulation

  • MC3R/MC4R agonism reduces food intake and body weight in preclinical studies.
  • Explored for anti-obesity applications.

Safety Profile

  • Generally well tolerated, though side effects may include nausea, flushing, and appetite suppression.
  • Prolonged use may increase pigmentation of moles and freckles.
  • For research use only; not approved for therapeutic use.

Summary

Melanotan 2 is a broad-spectrum melanocortin receptor agonist with activity across pigmentation, metabolism, and sexual function. Key highlights include:

  • Pigmentation enhancement for tanning and photoprotection
  • Sexual function research in male and female subjects
  • Metabolic studies exploring appetite suppression and fat regulation
  • Broader activity profile than Melanotan 1

This peptide is supplied as a lyophilized powder. Store at 2–8 °C, protected from light and moisture. For long-term preservation, keep unopened vials at −20 °C. After reconstitution, prepare solutions under sterile conditions, refrigerate at 2–8 °C, and use promptly. Avoid repeated freeze–thaw cycles.



1. Hadley ME, et al. Discovery and development of melanocortin peptides. *Ann N Y Acad Sci*. 1999;885:1–21. doi:10.1111/j.1749-6632.1999.tb08661.x

2. Wessells H, et al. Melanocortin receptor agonists and sexual function. *Urology*. 2000;55(5):755–759. doi:10.1016/S0090-4295(00)00451-4

3. Shadiack AM, et al. Melanotan II: effects on sexual behavior in male rats. *Pharmacol Biochem Behav*. 2003;76(3-4):355–362. doi:10.1016/S0091-3057(03)00218-1

4. Diamond LE, et al. Melanotan-II induces penile erection in men with psychogenic erectile dysfunction. *Urology*. 1999;54(4):755–759. doi:10.1016/S0090-4295(99)00226-9

5. Wessells H, et al. Effect of an MC4R agonist (Melanotan-II) on sexual desire and arousal in women. *J Clin Endocrinol Metab*. 2000;85(10):3862–3869. doi:10.1210/jcem.85.10.6895

6. Wikberg JE. Melanocortin receptors: structure and function. *Regul Pept*. 1999;85(1):95–105. doi:10.1016/S0167-0115(99)00088-3

7. Cowley MA, et al. Melanocortin receptors and regulation of appetite. *Nature*. 1999;400(6741):265–269. doi:10.1038/22307

8. Hruby VJ, et al. Structure-activity relationships of melanocortin peptides: design of potent MT-II analogues. *Peptides*. 1998;19(6):993–1000. doi:10.1016/S0196-9781(98)00053-2

9. Hadley ME, Dorr RT. Melanocortin peptide therapeutics: historical overview and future directions. *Peptides*. 2006;27(4):921–930. doi:10.1016/j.peptides.2005.05.019

10. van der Ploeg LH, et al. Melanotan-II (MT-II) enhances tanning and reduces appetite in humans. *Nat Med*. 2002;8(4):401–407. doi:10.1038/nm0402-401